He participated in the creation of murals of the Kyiv Opera House for the 1st Congress of Volost Executive Committees. As coauthors with Tymofii Boichuk he created the panel Blacksmith (1919) and the drawing From One Cauldron for the mural of the Lutsk barracks (1919). He participated in republican and All-Union art exhibitions. He initiated the creation of the textile department at the Kyiv Art Institute and headed it. Likewise, he taught at the Margelan Silk Weaving College, Tashkent Textile Institute, and Kyiv School of Applied Arts.

He was personally acquainted with Ivan Franko and Mykhailo Kotsiubynskyi. Their influence encouraged the artist to travel around Hutsulshchyna and study local life, art, and traditions.
After leaving for Central Asia in the 1930s, Serhiy Kolos managed to escape repression.
During the birth of the Sixties in Kyiv, the artist was invited as a lecturer to the fine arts section of the newly created Prolisok Creative Youth Club led by Les Taniuk. However, when the Sixtiers began to experience harassment, Kolos was dismissed from his position and banned from lecturing.

Serhiy Kolos is a prominent representative of Ukrainian modernism, and at the same time, one of the galaxy that made the ideological and artistic method of Boichukism a cultural phenomenon of his time.

As an artist, he masterfully worked with oil and watercolor painting, graphics, weaving, carpet weaving, etc. He had an encyclopedic knowledge of Ukrainian and world art. His scholarly works reveal the history and regional zoning of Ukrainian textiles, detail the typology of ornaments, production technologies, and many other artistic features.