As a printmaker, she worked in the techniques of stamp graphics, watercolors painting, and posters in a number of publishing houses: Kultura Publishing (1930), Vukoopspilka Publishing (1932-1934), Mystetstvo Publishing (1936-1939), and others.

In 1944-1946, she headed the etching workshop at the Kyiv Art Institute. In 1957-1960, she worked as a printer at Ukrreklamfilm. She also worked in the field of easel and book graphics.

She exhibited her works since 1917. Her personal exhibitions were held in Kyiv in 1984 and 2000.

Bura-Matsapura's artworks are kept in the National Art Museum of Ukraine, the National Museum of Taras Shevchenko in Kyiv, the Shevchenko National Reserve in Kaniv, the Pushkin House Museum of the Institute of Russian Literature in St. Petersburg, the Marko Vovchok Literary Memorial House-Museum in Nalchyk, and other museum and private collections.

Vira Bury-Matsapura's artworks are distinguished by their skillful drawing, authenticity of the depicted, and romanticism.