Roitburd’s artistic practice encompassed painting, graphics, installation, video, and performance. As a representative of the Ukrainian wave of postmodernism, he readily and boldly experimented, striving to convey his worldview as precisely as possible through his art and to communicate his key ideas and values to the viewer. His works are deeply meaningful and subtly ironic, at times imbued with eroticism, combining opposing dimensions. The artist skillfully manipulated classical art subjects, quoted world masterpieces, and turned to the values of various religions.

Roitburd was known not only as an artist but also as a public and political figure, blogger, and active participant in the Euromaidan movement. He was co-founder, art director, and president of the association New Art; chairman of the board of the Soros Center for Contemporary Art in Odesa; regional coordinator of the Cultural Heroes festival; and director of Gelman Gallery in Kyiv.

As a talented artist, Roitburd possessed a broad worldview, a refined sense of humor, and a sharp sense of justice. His artistic style is instantly recognizable, and his works are valued at tens of thousands of dollars. He is considered one of the most expensive and best-selling contemporary Ukrainian artists. In 2009, a painting from his series Farewell, Caravaggio! was sold at Phillips de Pury & Co in London for $97,000 — at the time, a record price for a Ukrainian painting.

Roitburd participated in more than 100 exhibitions and art projects. His works are held in the State Tretyakov Gallery in Moscow, the State Russian Museum in St. Petersburg, the Museum of Modern Art (MoMA) in New York, the Nasher Museum of Art at Duke University in Durham, the Odesa Fine Arts Museum, PinchukArtCentre in Kyiv, as well as in private collections.